The friars are not called to undertake any particular work or mission; rather they are called to proclaim the Gospel in whatever way it needs to be done in any given time or place.  Any kind of mission undertaken by the friars is to show the values of fraternity and minoritas, which are proper to friars in whatever they might be called to do.

Friars make themselves available for the service of the Church and to help others, gladly undertaking even the humblest of tasks without expecting compensation. In their work friars take care to not extinguish the spirit of prayer and devotion, as they are reminded in the Rule, but remain committed to fostering even more intense prayer in order to make work fruitful.

In addition to the apostolates below, individual friars also serve in healthcare, teaching, and various ministries to the poor, elderly and marginalized.